Founded in 1844, Issaquena County is one of 82 counties in the state of Mississippi. Historically, Issaquena County was formed from Washington County. The city of Mayersville is the county seat. With FIPS code of 55, Issaquena County has a population of 1,280 and area of 413 square miles (1,070 km2).
List of all cities in Issaquena County, MS alphabetically
| City/Town | Postal Code | Area Code |
| Grace, MS | 38745 | 662 |
| Mayersville, MS | 39113 | 662 |
| Valley Park, MS | 39177 | 601/769 |