Founded in 1918, Humphreys County is one of 82 counties in the state of Mississippi. Historically, Humphreys County was formed from Holmes, Sunflower, Washington and Yazoo Counties. The city of Belzoni is the county seat. With FIPS code of 53, Humphreys County has a population of 7,551 and area of 418 square miles (1,083 km2).
List of all cities in Humphreys County, MS alphabetically
| City/Town | Postal Code | Area Code |
| Bellewood, MS | 38754 | 662 |
| Belzoni, MS | 39038 | 662 |
| Caile, MS | 38754 | 662 |
| Isola, MS | 38754 | 662 |
| Louise, MS | 39097 | 662 |
| Midnight, MS | 39115 | 662 |
| Silver City, MS | 39115 | 662 |
| 39166 | 662 |