Founded in 1897, Cherokee County is one of 46 counties in the state of South Carolina. Historically, Cherokee County was formed from Spartanburg, Union, and York. The city of Gaffney is the county seat. With FIPS code of 21, Cherokee County has a population of 56,052 and area of 397 square miles (1,028 km2).
List of all cities in Cherokee County, SC alphabetically
| City/Town | Postal Code | Area Code |
| Blacksburg, SC | 29702 | 864 |
| Cherokee Falls, SC | 29702 | 864 |
| Gaffney, SC | 29340 | 864 |
| 29341 | 864 | |
| 29342 | 864 | |
| Kings Creek, SC | 29702 | 864 |