Founded in 1856, Wise County is one of 95 counties in the state of Virginia. Historically, Wise County was formed from Lee, Scott, and Russell Counties. The city of Wise is the county seat. With FIPS code of 195, Wise County has a population of 35,647 and area of 403 square miles (1,044 km2).
List of all cities in Wise County, VA alphabetically
| City/Town | Postal Code | Area Code |
| Andover, VA | 24215 | 276 |
| Appalachia, VA | 24216 | 276 |
| Big Stone Gap, VA | 24219 | 276 |
| Coeburn, VA | 24230 | 276 |
| East Stone Gap, VA | 24246 | 276 |
| Exeter, VA | 24216 | 276 |
| Pound, VA | 24279 | 276 |
| Saint Paul, VA | 24283 | 276 |
| Stonega, VA | 24216 | 276 |
| Wise, VA | 24293 | 276 |