Founded in 1908, Calhoun County is one of 46 counties in the state of South Carolina. Historically, Calhoun County was formed from Lexington and Orangeburg. The city of St. Matthews is the county seat. With FIPS code of 17, Calhoun County has a population of 14,165 and area of 392 square miles (1,015 km2).
List of all cities in Calhoun County, SC alphabetically
| City/Town | Postal Code | Area Code |
| Cameron, SC | 29030 | 803 |
| Creston, SC | 29030 | 803 |
| Fort Motte, SC | 29135 | 803 |
| Hammond Crossroads, SC | 29135 | 803 |
| Lone Star, SC | 29030 | 803 |
| Saint Matthews, SC | 29135 | 803 |
| Singleton, SC | 29135 | 803 |