Founded in 1888, Florence County is one of 46 counties in the state of South Carolina. Historically, Florence County was formed from Clarendon, Darlington, Marion, and Williamsburg. The city of Florence is the county seat. With FIPS code of 41, Florence County has a population of 136,504 and area of 804 square miles (2,082 km2).
List of all cities in Florence County, SC alphabetically
| City/Town | Postal Code | Area Code |
| Cartersville, SC | 29161 | 843 |
| Coward, SC | 29530 | 843 |
| Effingham, SC | 29541 | 843 |
| Florence, SC | 29501 | 843 |
| 29502 | 843 | |
| 29503 | 843 | |
| 29504 | 843 | |
| 29505 | 843 | |
| 29506 | 843 | |
| Johnsonville, SC | 29555 | 843 |
| Lake City, SC | 29560 | 843 |
| McKenzie Crossroads, SC | 29114 | 843 |
| Olanta, SC | 29114 | 843 |
| Pamplico, SC | 29583 | 843 |
| Peniel Crossroads, SC | 29161 | 843 |
| Poston, SC | 29555 | 843 |
| Quinby, SC | 29506 | 843 |
| Sardis, SC | 29161 | 843 |
| Scranton, SC | 29591 | 843 |
| Timmonsville, SC | 29161 | 843 |