Founded in 1854, Karnes County is one of 254 counties in the state of Texas. Historically, Karnes County was formed from Bexar County, DeWitt County, Goliad County, Gonzales County and San Patricio County. The city of Karnes City is the county seat. With FIPS code of 255, Karnes County has a population of 14,754 and area of 750 square miles (1,942 km2).
List of all cities in Karnes County, TX alphabetically
| City/Town | Postal Code | Area Code |
| Cestohowa, TX | 78113 | 830 |
| Coy City, TX | 78118 | 830 |
| Ecleto, TX | 78111 | 830 |
| Falls City, TX | 78113 | 830 |
| Gillett, TX | 78111 | 830 |
| Gillett, TX | 78116 | 830 |
| Hobson, TX | 78117 | 830 |
| Karnes City, TX | 78118 | 830 |
| Kenedy, TX | 78119 | 830 |
| McCoy, TX | 78113 | 830 |
| Panna Maria, TX | 78144 | 830 |
| Pawelekville, TX | 78113 | 830 |
| Runge, TX | 78151 | 830 |