Founded in 1870, Prentiss County is one of 82 counties in the state of Mississippi. Historically, Prentiss County was formed from Itawamba and Tishomingo Counties. The city of Booneville is the county seat. With FIPS code of 117, Prentiss County has a population of 24,996 and area of 415 square miles (1,075 km2).
List of all cities in Prentiss County, MS alphabetically
| City/Town | Postal Code | Area Code |
| Altitude, MS | 38829 | 662 |
| Blackland, MS | 38829 | 662 |
| Booneville, MS | 38829 | 662 |
| Burtons, MS | 38829 | 662 |
| Jumpertown, MS | 38829 | 662 |
| Marietta, MS | 38856 | 662 |
| New Site, MS | 38859 | 662 |
| Old Cairo, MS | 38829 | 662 |
| Osborne Creek, MS | 38829 | 662 |
| Pine Grove, MS | 38829 | 662 |
| Thrashers, MS | 38829 | 662 |
| Wheeler, MS | 38880 | 662 |