Founded in 1833, Holmes County is one of 82 counties in the state of Mississippi. Historically, Holmes County was formed from Yazoo County. The city of Lexington is the county seat. With FIPS code of 51, Holmes County has a population of 16,496 and area of 756 square miles (1,958 km2).
List of all cities in Holmes County, MS alphabetically
| City/Town | Postal Code | Area Code |
| Beelake, MS | 39169 | 662 |
| Cruger, MS | 38924 | 662 |
| Durant, MS | 39063 | 662 |
| Goodman, MS | 39079 | 662 |
| Kerin, MS | 38924 | 662 |
| Lexington, MS | 39095 | 662 |
| Mileston, MS | 39169 | 662 |
| Pickens, MS | 39146 | 662 |
| Possumneck, MS | 39192 | 662 |
| Tchula, MS | 39169 | 662 |
| Thornton, MS | 39169 | 662 |
| West, MS | 39192 | 662 |