Cities and Towns in Mississippi County, Missouri
Founded in 1842, Mississippi County is one of 114 counties in the state of Missouri. Historically, Mississippi County was formed from Scott County. The city of Charleston is the county seat. With FIPS code of 133, Mississippi County has a population of 12,538 and area of 413 square miles (1,070 km²).
List of all cities in Mississippi County, MO alphabetically
| City/Town | Postal Code | Area Code |
| Anniston, MO | 63820 | 573 |
| Bertrand, MO | 63823 | 573 |
| Charleston, MO | 63834 | 573 |
| Diehlstadt, MO | 63834 | 573 |
| East Prairie, MO | 63845 | 573 |
| Wolf Island, MO | 63881 | 573 |
| Wyatt, MO | 63882 | 573 |
Major Cities and Towns in Mississippi County, Missouri
Charleston
Area, Population, Zip Codes, Latitude, and Longitude
- Area: 3.12 sq mi
- Population: 5,496 (2020 Census)
- Zip Code: 63834
- Latitude: 37.3423° N
- Longitude: 89.1751° W
Location and History
Charleston, the county seat of Mississippi County, is located in the southeastern part of Missouri, near the confluence of the Mississippi and Ohio Rivers. The city was founded in 1839 and is named after Charles H. Sargent, a prominent figure in the region. Originally a river town, Charleston flourished due to its strategic location on the Mississippi River, which made it a key point for shipping and trade. The riverfront trade contributed significantly to the town’s early economic growth, with cotton, grain, and other agricultural goods being transported to larger cities. Charleston’s economy was also bolstered by the development of railroads in the late 19th century, which expanded its reach as a transportation hub. The town’s history also includes significant Civil War activity, as the area was a strategic point during the conflict. Charleston has evolved over the years but remains deeply rooted in its agricultural and riverfront heritage.
Major Schools and Landmarks
Charleston is served by the Charleston R-I School District, which includes Charleston High School and Charleston Middle School. The district is known for its strong academic programs and extracurricular activities. The town features several notable landmarks, including the Mississippi County Courthouse, which serves as the center of the county’s legal affairs. The town is also home to the Charleston City Park, which offers a wide range of recreational activities, including walking trails, sports fields, and a community center. The Old Courthouse, built in the late 1800s, is another landmark that reflects the city’s historical architecture. The area is also known for its annual events, including the Mississippi County Fair, which celebrates the region’s agricultural roots with exhibits, rides, and live entertainment. The scenic location near the Mississippi River offers opportunities for fishing, boating, and outdoor exploration, adding to Charleston’s charm as a small town with a rich history.
East Prairie
Area, Population, Zip Codes, Latitude, and Longitude
- Area: 2.13 sq mi
- Population: 3,358 (2020 Census)
- Zip Code: 63845
- Latitude: 36.9224° N
- Longitude: 89.1711° W
Location and History
East Prairie, located in the heart of Mississippi County, Missouri, was founded in the 1850s and is situated about 15 miles northeast of Charleston. The town’s name originates from the wide, flat prairie lands in the area, which were ideal for farming and agricultural development. Historically, East Prairie was primarily a farming community, with rice and cotton as major crops grown in the region. The establishment of the railroad in the late 19th century further accelerated the town’s growth, providing a reliable means for shipping goods to markets across the country. Over time, East Prairie became known as a center for agriculture, with the local economy still relying heavily on farming, particularly rice cultivation. The town also saw growth during the mid-20th century with the expansion of local industry and services. East Prairie’s small-town atmosphere has remained intact, even as it has adapted to modern times, with farming and agriculture continuing to play a central role in the community’s identity.
Major Schools and Landmarks
East Prairie is served by the East Prairie R-II School District, which includes East Prairie High School and East Prairie Middle School. The district has a reputation for providing quality education, and the high school sports teams are an important part of community life. Among the town’s landmarks is the East Prairie City Park, which offers a place for outdoor recreation, including picnicking, sports fields, and walking trails. The park is a hub for local events, such as the annual East Prairie Rice Festival, which celebrates the area’s agricultural heritage with food, music, and contests. The town also boasts a number of historical buildings and homes, many of which date back to the early 20th century. Agriculture remains central to East Prairie’s identity, with rice fields and other crops still visible in the surrounding landscape. The town’s close-knit community, agricultural events, and rural charm make it an appealing destination for those seeking a quiet lifestyle with strong connections to the land.
Blodgett
Area, Population, Zip Codes, Latitude, and Longitude
- Area: 0.68 sq mi
- Population: 277 (2020 Census)
- Zip Code: 63824
- Latitude: 36.6971° N
- Longitude: 89.2373° W
Location and History
Blodgett, located in the northeastern part of Mississippi County, is a small, unincorporated community with a rich agricultural heritage. The town was established in the late 19th century and was named after a local landowner, W.H. Blodgett. Historically, Blodgett developed as a farming community, with crops such as cotton, rice, and soybeans being integral to its economy. The town remained small throughout the 20th century, with farming and local industry serving as the main sources of income for its residents. Blodgett is situated along the route that connects Charleston to other towns in Mississippi County, making it an important stop for travelers and traders. Over the years, the town has remained relatively unchanged, with the majority of its residents involved in farming and related industries. Despite its small size, Blodgett has maintained a strong sense of community and continues to celebrate its rural roots.
Major Schools and Landmarks
Blodgett is part of the East Prairie R-II School District, so local students attend school in the nearby East Prairie district. The town itself is quite small, with few public facilities, but the nearby city of East Prairie provides many of the resources its residents need. While Blodgett lacks major landmarks, it is surrounded by agricultural landscapes that make it an important part of Mississippi County’s rural identity. The surrounding farmland offers scenic views of the area’s extensive crop fields, and residents and visitors alike enjoy the region’s quiet, rural atmosphere. Agriculture remains the lifeblood of the community, with crops like rice and soybeans playing a central role in the local economy. Blodgett’s small size and focus on farming make it a peaceful town where the agricultural heritage is preserved in everyday life.
