Founded in 1842, Mississippi County is one of 114 counties in the state of Missouri. Historically, Mississippi County was formed from Scott County. The city of Charleston is the county seat. With FIPS code of 133, Mississippi County has a population of 12,538 and area of 413 square miles (1,070 km2).
List of all cities in Mississippi County, MO alphabetically
| City/Town | Postal Code | Area Code |
| Anniston, MO | 63820 | 573 |
| Bertrand, MO | 63823 | 573 |
| Charleston, MO | 63834 | 573 |
| Diehlstadt, MO | 63834 | 573 |
| East Prairie, MO | 63845 | 573 |
| Wolf Island, MO | 63881 | 573 |
| Wyatt, MO | 63882 | 573 |