Founded in 1836, DeSoto County is one of 82 counties in the state of Mississippi. Historically, DeSoto County was formed from Monroe and Washington Counties. The city of Hernando is the county seat. With FIPS code of 33, DeSoto County has a population of 188,633 and area of 478 square miles (1,238 km2).
List of all cities in DeSoto County, MS alphabetically
| City/Town | Postal Code | Area Code |
| Days, MS | 38641 | 662 |
| Glover, MS | 38680 | 662 |
| Hernando, MS | 38632 | 662 |
| Horn Lake, MS | 38637 | 662 |
| Jago, MS | 38637 | 662 |
| Lake Cormorant, MS | 38641 | 662 |
| Lake View, MS | 38680 | 662 |
| Memphis, MS | 38680 | 662 |
| Mineral Wells, MS | 38654 | 662 |
| Nesbit, MS | 38651 | 662 |
| Newport, MS | 38641 | 662 |
| Olive Branch, MS | 38654 | 662 |
| Poplar Corners, MS | 38680 | 662 |
| Sacred Heart League, MS | 38686 | 662 |
| Southaven, MS | 38671 | 662 |
| 38672 | 662 | |
| Walls, MS | 38680 | 662 |
| 38686 | 662 | |
| West Days, MS | 38641 | 662 |