Founded in 1880, Hughes County is one of 66 counties in the state of South Dakota. Historically, Hughes County was formed from Buffalo County. The city of Pierre is the county seat. With FIPS code of 65, Hughes County has a population of 17,694 and area of 741 square miles (1,919 km2).
List of all cities in Hughes County, SD alphabetically
| City/Town | Postal Code | Area Code |
| Ames, SD | 57501 | 605 |
| Blunt, SD | 57522 | 605 |
| Canning, SD | 57501 | 605 |
| Degray, SD | 57522 | 605 |
| Eakin, SD | 57501 | 605 |
| Fairbank, SD | 57501 | 605 |
| Francis, SD | 57501 | 605 |
| Harrold, SD | 57536 | 605 |
| Joe Creek, SD | 57536 | 605 |
| Oahe, SD | 57501 | 605 |
| Okobojo, SD | 57501 | 605 |
| Pierre, SD | 57501 | 605 |
| Rousseau, SD | 57501 | 605 |
| Wendt, SD | 57501 | 605 |