Founded in 1875, Brule County is one of 66 counties in the state of South Dakota. Historically, Brule County was formed from Charles Mix County. The city of Chamberlain is the county seat. With FIPS code of 15, Brule County has a population of 5,242 and area of 819 square miles (2,121 km2).
List of all cities in Brule County, SD alphabetically
| City/Town | Postal Code | Area Code |
| Bijou Hills, SD | 57325 | 605 |
| Chamberlain, SD | 57325 | 605 |
| 57326 | 605 | |
| Kimball, SD | 57355 | 605 |
| Lyonville, SD | 57355 | 605 |
| Ola, SD | 57325 | 605 |
| Pukwana, SD | 57370 | 605 |
| Saint Joseph Indian School, SD | 57326 | 605 |
| Shelby, SD | 57370 | 605 |