Founded in 1826, Pickens County is one of 46 counties in the state of South Carolina. Historically, Pickens County was formed from Pendleton District. The city of Pickens is the county seat. With FIPS code of 77, Pickens County has a population of 132,229 and area of 512 square miles (1,326 km2).
List of all cities in Pickens County, SC alphabetically
| City/Town | Postal Code | Area Code |
| Cateechee, SC | 29667 | 864 |
| Central, SC | 29630 | 864 |
| Clemson, SC | 29631 | 864 |
| 29632 | 864 | |
| 29633 | 864 | |
| 29634 | 864 | |
| Clemson University, SC | 29632 | 864 |
| 29634 | 864 | |
| Easley, SC | 29640 | 864 |
| 29641 | 864 | |
| 29642 | 864 | |
| Liberty, SC | 29657 | 864 |
| Norris, SC | 29667 | 864 |
| Pickens, SC | 29671 | 864 |
| Piedmont, SC | 29642 | 864 |
| Powdersville, SC | 29642 | 864 |
| Six Mile, SC | 29682 | 864 |
| Sunset, SC | 29685 | 864 |