Founded in 1818, Madison County is one of 114 counties in the state of Missouri. Historically, Madison County was formed from Cape Girardeau and Sainte Genevieve counties. The city of Fredericktown is the county seat. With FIPS code of 123, Madison County has a population of 12,652 and area of 497 square miles (1,287 km2).
List of all cities in Madison County, MO alphabetically
| City/Town | Postal Code | Area Code |
| Allbright, MO | 63655 | 573 |
| Big Creek, MO | 63655 | 573 |
| Buckhorn, MO | 63655 | 573 |
| Cobalt City, MO | 63645 | 573 |
| Fredericktown, MO | 63645 | 573 |
| Gravelton, MO | 63655 | 573 |
| Marquand, MO | 63655 | 573 |
| Millcreek, MO | 63645 | 573 |
| Mine La Motte, MO | 63645 | 573 |
| Womack, MO | 63645 | 573 |