Founded in 1812, Cape Girardeau County is one of 114 counties in the state of Missouri. Historically, Cape Girardeau County was one of the five original counties. The city of Jackson is the county seat. With FIPS code of 31, Cape Girardeau County has a population of 82,113 and area of 579 square miles (1,500 km2).
List of all cities in Cape Girardeau County, MO alphabetically
| City/Town | Postal Code | Area Code |
| Altenburg, MO | 63732 | 573 |
| Apple Creek, MO | 63769 | 573 |
| Burfordville, MO | 63739 | 573 |
| Cape Girardeau, MO | 63701 | 573 |
| 63702 | 573 | |
| 63703 | 573 | |
| Daisy, MO | 63743 | 573 |
| Delta, MO | 63744 | 573 |
| Dutchtown, MO | 63745 | 573 |
| Friedheim, MO | 63747 | 573 |
| Gordonville, MO | 63701 | 573 |
| Gordonville, MO | 63752 | 573 |
| Jackson, MO | 63755 | 573 |
| Millersville, MO | 63766 | 573 |
| New Wells, MO | 63732 | 573 |
| Oak Ridge, MO | 63769 | 573 |
| Old Appleton, MO | 63770 | 573 |
| Perryville, MO | 63747 | 573 |
| Pocahontas, MO | 63779 | 573 |
| Whitewater, MO | 63785 | 573 |